FAQs on Pituitary Tumors

What are pituitary tumors, and how common are they?

Pituitary tumors are growths that develop in the pituitary gland, a small organ which secretes essential hormones and is located behind the nose at the base of the brain. Studies show that pituitary adenomas are increasing in incidence (between 3.9 and 7.4 cases per 100,000 per year) and prevalence (approximately 1 case per 1000 of the general population). They make up approximately 10% of brain tumors. Pituitary tumors can occur in people of any age but they are most often found in older adults aged between 30 and 50.

Can pituitary tumors be hereditary, and are there any genetic factors that increase the risk of developing these tumors?

Most people who develop pituitary tumors do not have a family history of the disease. Many people with pituitary tumors have no known risk factors.
However, rarely, pituitary tumors can run in families. When this happens, they are often found as part of a genetic syndrome that may involve other types of tumors as well. Like multiple endocrine neoplasias (MEN syndrome).

What are the typical symptoms of a pituitary tumor?

Symptoms may result from pressure on the brain or nearby structures.
Common symptoms include headaches, vision changes, hormonal imbalances, and fatigue.

How do pituitary tumors affect hormone levels in the body, and what are the long-term effects of hormonal imbalances caused by these tumors?

Pituitary tumors are of two types functioning and non-functioning tumors:

Functioning tumors: They secrete excess levels of hormones. Symptoms depend on which hormone is in excess. Tumors which secrete excess growth hormone can cause changes in facial features such as enlargement of the nose, thickening of lips, enlarged hands and feet. Tumors which lead to excess cortisol production (also called Cushing’s syndrome) can lead to obesity, Diabetes, Hypertension, and decreased immunity. Tumors producing excess prolactin can cause menstrual irregularities, and failure to conceive and have children in women.
Nonfunctioning tumors: They reduce the levels of hormones like thyroid hormones, cortisol, and growth hormone by pressing on the normal pituitary gland. causing problems like fatigue, weight problems, and menstrual irregularities.